2012 Fiscal Year Final Research Report
Development of high-throughput analysis formouth odor
| Project/Area Number |
22592336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ITO Hiro-o 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (40213079)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Shigeki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20226038)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUI Makoto 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (50325289)
NAKAO Michiyasu 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60550001)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 口臭検査 / 歯周病 / 有機化学 / エルマン試薬 / チオール捕捉反応 / ハイスループット処理 / メチルメルカプタン |
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| Research Abstract |
In order to develop a high-sensitive method of analysis of methyl mercaptan, which is the major cause of odor in the mouth air and has been suggested to be related to periodontal disease, we have designed and synthesized modified Ellmann’s reagents for fluorescent labeling of methyl mercaptan. In addition, we have successfully analyzed samples containing known concentration of methyl mercaptan utilizing these reagents.
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