2012 Fiscal Year Final Research Report
Varicella-zoster virus IE62 immunologically cross-reacts with Brain-derived nerve growth factor and causes allodynia of herpes zoster
| Project/Area Number |
22600003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | University of Toyama |
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Principal Investigator |
SHIRAKI Kimiyasu 富山大学, 大学院・医学薬学研究部(医学), 教授 (50135745)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ウイルス / 帯状疱疹 / 疼痛 |
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| Research Abstract |
Varicella-zoster virus （VZV) immediate early protein 62 （IE62) is a major transcriptional activator and anti-IE62 monoclonal antibody among three monoclonal antibodies recognized brain-derived nerve growth factor （BDNF). BDNF causes hyperesthesia and allodynia.This antibody augmented the BDNF activity and its intrathecal injection induced allodynia in the nerve-injured mice. Histological study of the skin of mice infected cutaneously revealed that nerve ending around herpes simplex virus （HSV) lesion increased 10 times in the number of nerve endings. Keratinocytes around HSV lesion induced nerve growth factor and this may have increased the number of nerve endings. Thus the increase in the number of nerve endings indicated the increase in the number of pain spots and this may cause the pain in the skin lesions of herpes zoster
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[Journal Article] Contribution of spinal galectin-3 to acute herpetic allodynia in mice2012
Author(s)
Takasaki I, Taniguchi K, Komatsu F, Sasaki A, Andoh T, Nojima H, Shiraki K, Hsu DK, Liu FT, Kato I, Hiraga K, Kuraishi Y
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Journal Title
Pain
Volume: 153
Pages: 585-592
DOI
Peer Reviewed
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[Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo2012
Author(s)
Himaki T, Masui Y, Chono K, Daikoku T, Takemoto M, Haixia B, Okuda T, Suzuki H, Shiraki K
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Journal Title
Antiviral Research
Volume: 93
Pages: 301-304
DOI
Peer Reviewed
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[Journal Article] Shimizu T, Sawamura R, Kim KH, Kim KH, Lee SH, Lee YS, Kim TG, Kai H, Yoshida H, Watanabe W, Matsuno K, Shiraki K, and Kurokawa M2011
Author(s)
Shimizu T, Sawamura R, Kim KH, Kim KH, Lee SH, Lee YS, Kim TG, Kai H, Yoshida H, Watanabe W, Matsuno K, Shiraki K, and Kurokawa M
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Journal Title
Journal of Traditional Medicines
Volume: 28
Pages: 115-127
Peer Reviewed
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[Journal Article] Efficacy of brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of antiherpetic efficacies2011
Author(s)
Shimizu T, Takeshita Y, Takamori Y, Kai H, Sawamura R, Yoshida H, Watanabe W, Tsutsumi A, Park YK, Yasukawa K, Matsuno K, Shiraki K, Kurokawa K
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Journal Title
EvidenceBased Complementary and Alternative Medicine
Volume: ID 976196
Pages: 9
DOI
Peer Reviewed
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[Journal Article] Widespread circulation of echovirus type 13 demonstrated by increasedseroprevalence in Toyama, Japan between 2000 and 20032010
Author(s)
Iwai M, Yoshida H, Obara M, HorimotoE, Nakamura K, Takizawa T, Kurata T, Mizuguchi M, Daikoku T, Shiraki K
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Journal Title
Clinical and Vaccine Immunology
Volume: 17
Pages: 764-770
DOI
Peer Reviewed
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