The mechanism of hyperalgesia in the spinal dorsal horn revealed by imaging of neuronal activity

2012 Fiscal Year Final Research Report

• Project/Area Number: 22600005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: University of Fukui
• Principal Investigator: IKEDA Hiroshi 福井大学, 大学院・工学研究科, 教授 (80377473)
• Project Period (FY): 2010 – 2012
• Keywords: 痛覚 / イメージング / 脊髄後角 / グリア細胞 / 神経可塑性

Research Abstract

There are distinct glia-related mechanisms for the central sensitization in different persistent pain, that is microglia-related and astrocyte-related mechanisms in neuropathic and inflammatory pain, respectively.

Research Products

• [Journal Article] Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat (2012)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Journal Title: Molecular Pain Volume: 8
  • Peer Reviewed
• [Journal Article] Effect of dietary zinc deficiency on ischemic vulnerability of the brainEffect of dietary zinc deficiency on ischemic vulnerability of the brain (2012)
  • Author(s): Omata N, Murata T, Maruoka N, Ikeda H, Mitsuya H, Mizuno T, Mita K, Asano M, Kiyono Y, Okazawa H, Wada Y
  • Journal Title: Neuroscience Letters Volume: 531 Pages: 10-13
  • Peer Reviewed
• [Journal Article] Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Journal Title: Brain Research Volume: 1349 Pages: 32-40
  • Peer Reviewed
• [Journal Article] Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats (2010)
  • Author(s): Ueda K, Hirose M, Murata E, Takatori M, Ueda M, Ikeda H, Shigemi K
  • Journal Title: Journal of Pharmacological Science Volume: 112 Pages: 438-443
  • Peer Reviewed
• [Presentation] Contribution of the descending pain inhibitory system to the analgesic effect by smelling the aroma oil (2012)
  • Author(s): 高須 俊太郎, 池田 弘, 村瀬 一之, 竹内 翔汰
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-09-19
• [Presentation] 前帯状回における神経興奮の長期増強へのアストロサイトの関与 (2012)
  • Author(s): 池田 弘, 林 努, 村瀬 一之
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-09-19
• [Presentation] Astrocyte involves in the long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain (2012)
  • Author(s): H. Ikeda, K. Mochizuki, K. Murase
  • Organizer: NIPS-WS 2012 Central Neuroplasticity in Sensory Emotional Link
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2012-09-13
• [Presentation] Differential contribution of microglia and astrocytes to the central sensitization under peripheral nerve injury and tissue inflammation (2011)
  • Author(s): 池田 弘 , 村瀬 一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2011-09-16
• [Presentation] Agumentation of neuronal excitability by glial cells in the rat spinal dorsal horn under persistent pain state revealed by optical imaging with voltage-sensitive dye. (2011)
  • Author(s): 村山 美郷 , 池田 弘 , 村瀬 一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2011-09-16
• [Presentation] Contribution of emotional and descending pain inhibitory system in the brain to analgesia effect of lemon odor (2011)
  • Author(s): 竹内 祥太 , 池田 弘 , 村瀬 一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2011-07-22
• [Presentation] Role of glial cells to the neuronal plasticity in the spinal dorsal horn under hyperalgesia (2011)
  • Author(s): 池田 弘, 村瀬 一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2011-07-22
• [Presentation] Contribution of the glial activity to the facilitation of neuronal excitation in the rat spinal dorsal horn under neuropathic pain (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] Involvement of protein kinases in pain-related synaptic plasticity in the rat central nucleus of the amygdala (2010)
  • Author(s): Kiritoshi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] The mechanism of long-term facilitation of optically-recorded neuronal excitation and the effect of mu-opioid receptor agonist DAMGO in the rat central nucleus of the amygdala (2010)
  • Author(s): Ebuchi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] Contribution of glial cells on the optically-recorded neuronal excitation in the rat spinal dorsal horn under neuropathic pain (2010)
  • Author(s): Murayama M, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04