2012 Fiscal Year Final Research Report
Study on structure and function of novel tachykinin peptides
| Project/Area Number |
22600008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tetsuya 宮崎大学, 医学部, 准教授 (20264369)
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| Research Collaborator |
NAKAYAMA Rumi 宮崎大学, 医学部, 研究員 (00609034)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 疼痛 / ペプチド / 脊髄 / 神経薬理 |
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| Research Abstract |
Endokinins are novel tachykinin peptides, in which endokinin C/D (EKC/D) has the inhibitory effect on noxious stimulation. Replacement of EKC/D with D-type amino acid remarkably extended this effect. Also, intrathecal administration of hemokinin-1, another novel tachykinin peptide, did not induce thermal hyperalgesia. This effect of hemokinin-1 was caused by 3 amino acids consisting ofN-terminal region of this peptide.
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