2012 Fiscal Year Final Research Report
Induction of P2Y receptors in the spinal cord following peripheral nerve injury.
| Project/Area Number |
22600012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kimiko 兵庫医科大学, 医学部, 助教 (70418961)
MORIYAMA Kazuhide 兵庫医科大学, 医学部, 助教 (30301659)
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| Project Period (FY) |
2010 – 2012
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| Keywords | P2Y受容体 / 神経障害性疼痛 / 脊髄後角 / マイクログリア / ATP |
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| Research Abstract |
Peripheral nerve injury can trigger neurological abnormalities, including neuropathic pain. Recent evidence shows that glial cells in the spinal cord play important roles in the mechanisms of neuropathic pain. In this study, we show that microglial P2Y receptors activated by peripheral nerve injury may play a key role in the development of neuropathic pain.
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