2012 Fiscal Year Final Research Report
Analysis of age-related sensory organ defects using Chemical Biology
| Project/Area Number |
22603017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
ケミカルバイオロジー
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
TSUDA Leo 独立行政法人国立長寿医療研究センター, 創薬モデル動物開発研究PT, プロジェクトリーダー (30333355)
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| Co-Investigator(Kenkyū-buntansha) |
LIM Young-mi 国立長寿医療研究センター, 創薬モデル動物開発研究PT, 研究員 (60421898)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 難聴 / ショウジョウバエ / 感覚器 / ケミカルバイオロジー / ストレス応答 / 転写抑制 / 加齢 |
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| Research Abstract |
The survival of sensory neurons is essential for the long-term maintenance of sensory function, and defects in sensory cells survival lead to the onset of age-related sensory defects such as hearing loss or retinitis pigmentosa. In this study we have shown that there seems to be a mechanism, which represses the expression of apoptotic genes, under stress signalling of Drosophila sensory organs. We expect that the mechanism for maintaining photoreceptor cells will lead to the comprehensive understanding of sensory defects, such as age-related hearing disorders.
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