2012 Fiscal Year Final Research Report
Are affective disorder for school-age children influenced by dietary habit and environmental chemical compounds ?
| Project/Area Number |
22610011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | Oita University |
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Principal Investigator |
SAKAI Kumiko 大分大学, 全学研究推進機構, 助教 (60225753)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Kenji 九州大学, 農学部, 教授 (50205704)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 情動障害 / モノアミンオキシダーゼ / 安息香酸亜鉛 |
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| Research Abstract |
Recently, children with learning disabilities and affective disorder are increasing.We previously reportedthat zinc benzoate, a contaminating environmentalcompound, inhibited A-type monoamine oxidase (MAOA). In this report, we investigated how zinc and zinc benzoate influenced activity of MAOA. Microarrayanalysis of brain tissues isolated from mice fed zinc, zinc benzoate or sodium benzoate diets revealed that the regulation of genes involved calcium signal transduction and neuroactive ligand-receptor interactionwere changed.
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