An application of molecular imaging using TOF-PET/CTfor radiation treatment planning

2012 Fiscal Year Final Research Report

• Project/Area Number: 22611012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical Physics/Radiological Technology
• Research Institution: Kyushu University
• Principal Investigator: SASAKI Masayuki 九州大学, 医学研究院, 教授 (40240907)
• Co-Investigator(Kenkyū-buntansha): HIRATA Hideki 九州大学, 医学研究院, 教授 (70173242) ; YABUUCHI Hidetake 九州大学, 医学研究院, 准教授 (70380623) ; ARIMURA Hidetaka 九州大学, 医学研究院, 准教授 (20287353)
• Co-Investigator(Renkei-kenkyūsha): ABE Koichiro 九州大学, 大学病院, 助教 (00380387) ; SHIOYAMA Yoshiyuki 九州大学, 大学病院, 助教 (10323304) ; OYA Nobuyoshi 九州大学, 大学病院, 技官 (70380475)
• Project Period (FY): 2010 – 2012
• Keywords: PET / TOF / 分子イメージング / 放射線治療

Research Abstract

The purpose of this study is to establish a method for effectively utilizing molecular imaging using time-of-flight (TOF)- PET / CT system for radiation treatment planning. We found that the TOF correction is useful for improving the quantitative and diagnostic performance of PET/CT. We determined the optimal examination conditions, the methods to compensate respiratory motion and the thresholds to extract tumor contour. We developed a program to use PET/CT images to radiation treatment planning and found that it was useful as a support tool for planning.

Research Products

• [Journal Article] Benefits of point-spread-function and time-of-flight for PET/CT image quality in relation to the body mass index and injected dose. (2013)
  • Author(s): Akamatsu G, Mitsumoto K, Ishikawa K, Taniguchi T, Ohya N, Baba S, Abe K, Sasaki M.
  • Journal Title: Clin Nucl Med.
  • Peer Reviewed
• [Journal Article] Improvement in PET/CT image quality with a combination of the point-spread-function and time-offlight in relation to the reconstruction parameters. (2012)
  • Author(s): Akamatsu G, Ishikawa K, Mitsumoto K, Taniguchi T, Ohya N, Baba S, Abe K,Sasaki M
  • Journal Title: J Nucl Med. Volume: 53 Pages: 1716-22
  • Peer Reviewed
• [Journal Article] determination of the optimal acquisition protocol of breath-hold PET/CT for the diagnosis of thoracic lesions. (2011)
  • Author(s): Mitsumoto K, Abe K, Sakaguchi Y, Zhang T, Tachiya Y, Ohya N, Baba S, Sasaki M
  • Journal Title: Nucl Med Commun. Volume: 32 Pages: 1148-54
  • Peer Reviewed
• [Journal Article] Phantom study on three-dimensional target volume delineation by PET/CT-based auto-contouring. (2010)
  • Author(s): Zhang T, Tachiya Y, Sakaguchi Y, Mitsumoto K, Mitsumoto T, Ohya N, Sasaki M.
  • Journal Title: Fukuoka Igaku Zasshi. Volume: 101 Pages: 238 -246
  • Peer Reviewed
• [Presentation] The influences of point-spread-function and time-of-flight on SUV of lymph node metastasis in FDG-PET. (2012)
  • Author(s): Akamatsu G, Mitsumoto K, Taniguchi T, Komiya I, Ohya N, Abe K, Baba S, Sasaki M.
  • Organizer: 59th Annual Meeting, Society of Nuclear Medicine.
  • Place of Presentation: Miami Beach, Florida, USA.
  • Year and Date: 20120609-13
• [Presentation] PSF および TOF 補正 PET 画像における至適再構成条件の検討. (2011)
  • Author(s): 張鉄嬌,光元勝彦, 石川香,赤松剛,大屋信義,高木真三,佐々木雅之.
  • Organizer: 第30回日本核医学技術学会総会学術大会.
  • Place of Presentation: さいたま市
  • Year and Date: 20111111-13
• [Presentation] Impact of PSF and TOF on improving clinical PET/CT images in relation to BMI and injected dose. (2011)
  • Author(s): Akamatsu G, Ishikawa K, Zhang T, Takagi S, Ohya N, Mitsumoto K, Enomoto M, Yamaguchi K, Sasaki M.
  • Organizer: EANM'11 - Annual Congress of the European Association of Nuclear Medicine.
  • Place of Presentation: Birmingham/UK
  • Year and Date: 20111015-19
• [Presentation] Determination of the Optimal Acquisition Protocol of Breath-Hold PET/CT for the Diagnosis of Thoracic Lesions. (2011)
  • Author(s): Mitsumoto K, Abe K, Sakaguchi Y, Zhang T, Tachiya Y, Ohya N, Sasaki M.
  • Organizer: EANM'11 - Annual Congress of the European Association of Nuclear Medicine.
  • Place of Presentation: Birmingham/UK
  • Year and Date: 20111015-19
• [Presentation] Computerized Estimation of Possible Clinical Target Volume Based on Multimodality Images Using A Dual Active Contour Model. (2011)
  • Author(s): Kuwazuru J, Arimura H, Shioyama Y, Taniyama E, Sasaki M, Magome T, Nakamura K, Honda H, Toyofuku F, Hirata H.
  • Organizer: ASRTO (American Society for Radiation Oncology) 53rd annual meeting.
  • Place of Presentation: Miami Beach, USA.
  • Year and Date: 20111002-06
• [Presentation] Impact of PSF and TOF on improving PET/CT images using a large phantom. (2011)
  • Author(s): Akamatsu G, Mitsumoto K, Taniguchi T,Kasahara Y, Ohya N, Umezu Y, Komiya I, Tsutsui Y, Sasaki M
  • Organizer: 6th Japan-Korea Joint Meeting on Medical Physics. 11th Asia-Oceania Congress of Medical Physics (JKMP-AOCMP Congress 2011).
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20110928-1001