A new MRI method for axonal activity visualization

2012 Fiscal Year Final Research Report

• Project/Area Number: 22613004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Non-invasive neuroimaging
• Research Institution: National Institute of Information and Communications Technology
• Principal Investigator: LIU Guoxiang 独立行政法人情報通信研究機構, 未来ICT研究所脳情報通信研究室, 主任研究員 (40358817)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Yoshichika 大阪大学, 学内共同利用施設等, 教授 (00174897)
• Project Period (FY): 2010 – 2012
• Keywords: 白質での神経活動 / MR計測

Research Abstract

A new MRI pulse sequence was developed for axonal activity visualization. The activities at white matter of human brain, especially at corpus callosum were investigated using the proposed method. And we found the responds during tapping and visual stimuli. In rat studies, the activities at axons connected to amygdala were detected using MRI.

Research Products

• [Journal Article] Multilayered, core/shell nanoprobes based on magnetic ferric oxide particles and quantum dots for multimodality imaging of breast cancer tumors (2012)
  • Author(s): Ma Q, Nakane Y, Mori Y, Hasegawa M, Yoshioka Y, Watanabe TM, Gonda K, Ohuchi N, Jin T
  • Journal Title: Biomaterials Volume: Vol 33 Pages: 8486-8494
  • DOI: DOI: 10. 1016/ j. biomaterial s. 2012. 07. 051
  • Peer Reviewed
• [Journal Article] 19F MRI Monitoring of Gene Expression in Living Cells through Cell-Surface b-Lactamase Activity (2012)
  • Author(s): Matsushita H. Mizukami S. Mori Y. Sugihara F. Shirakawa M. Yoshioka Y. Kikuchi K
  • Journal Title: Chem Bio Chem Volume: Vol 13 Pages: 1579-1583
  • DOI: DOI: 10.1002/cbic.201200331
  • Peer Reviewed
• [Journal Article] Critical role of Tribl in differentiation of tissue-resident M2-like macrophages (2012)
  • Author(s): Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi 0, Akira S
  • Journal Title: Nature Volume: Vol 495 Pages: 524-528
  • DOI: DOI:10.1038/nature11930
  • Peer Reviewed
• [Journal Article] Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice (2011)
  • Author(s): Wang T. Takikawa Y. Satoh T. Yoshioka Y. Kosaka K. Tatemichi Y. Suzuki K
  • Journal Title: Hepatology Research Volume: Vol 41 No.1 Pages: 87-92
  • DOI: DOI :10. 1111 / j . 1872-034X. 2010. 00747. x
  • Peer Reviewed
• [Journal Article] MR Contrast in Mouse Lymph Nodes with Subcutaneous Administration of Iron Oxide Particles (2010)
  • Author(s): Mori Y. Umeda M. Fukunaga M. Ogasawara K. Yoshioka Y
  • Journal Title: Size Dependency Volume: Vol 10, No.4 Pages: 219-227
  • DOI: DOI: http://dx.doi.org/10.2463/mrms.10.2 19
  • Peer Reviewed
• [Journal Article] In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemic and stroke (2010)
  • Author(s): Hayasaka N. Nagai N. Kawao N. Niwa A. Yoshioka Y. Mori Y. Shigeta H. Kashiwagi N. Miyazawa M. Stou T. Higashino H. Matsuo 0. Murakami T
  • Journal Title: PLoS One Volume: Vol 7, No.2 Pages: e32342
  • URL: http://www.plosone.org/article/info %3Adoi%2F10. 1371%2F journal. pone. 003 2342
  • Peer Reviewed
• [Journal Article] Correction of Shearing Distortions in Echo-Planar Imaging (2010)
  • Author(s): Liu G. Oshio K. Ogawa S. Murata T.
  • Journal Title: IEEE Trans. on Magnetics Volume: Vol. 46, No. 7 Pages: 2628-2634
  • DOI: DOI: 10. 1109/TMAG. 2010. 2041785
  • Peer Reviewed
• [Journal Article] The brain mapping of the retrieval of conditioned taste aversion memory using manganese-enhancedmagnetic resonance imaging in rats (2010)
  • Author(s): Inui-Yamanomoto C. Yoshioka Y. Inui T. Sasaki K. S. Ooi Y. Ueda K. Seiyama A. Ohzawa I.
  • Journal Title: Neuroscience Volume: Vol. 167, No. 2 Pages: 199-204
  • DOI: DOI: http://dx.doi.org/10.1016/j.neurose ience. 2010. 02. 027
  • Peer Reviewed
• [Journal Article] Brain Temperature Measured by Proton Magnetic Resonance Spectroscopy Predicts Cerebral Hyperperfusion after Carotid Endarterectomy (2010)
  • Author(s): Murakami T. Ogasawara K. Yoshioka Y. Ishigaki D. Sasaki M. Kudo K. Aso K. Nishimoto H
  • Journal Title: Radiology Volume: Vol. 46, No. 7 Pages: 924-931
  • DOI: 924-931
  • Peer Reviewed
• [Presentation] White matter fMRI using intra-voxel phase gradient (2012)
  • Author(s): Liu G
  • Organizer: 18th Annual meeting of Human Brain Mapping
  • Place of Presentation: China National Convention Center, Bei Jing, China
  • Year and Date: 2012-06-14
• [Presentation] White matter fMRI using dual-spin echo EPI (2011)
  • Author(s): Liu G
  • Organizer: 17th Annual meeting of Human Brain Mapping
  • Place of Presentation: Centre des Congres de Quebec, Quebec City, Canada
  • Year and Date: 2011-09-01
• [Presentation] Possible origin of negative BOLD response (2010)
  • Author(s): Liu G.
  • Organizer: 16th Annual meeting of Human Brain Mapping, 2010/6/10 Catalonia Palace of Congresses
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-10