2012 Fiscal Year Final Research Report
A new strategy of the regulation of metabolic syndrome and cardiovascular diseases by the pharmacological targeting of cellular mechanical stress reactions.
| Project/Area Number |
22616007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Mechanobiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Maki 岩手医科大学, 薬学部, 助教 (40365185)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMATAKI Akihisa 岩手医科大学, 医学部, 助教 (60360004)
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| Project Period (FY) |
2010 – 2012
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| Keywords | メカニカルストレス / メタボリックシンドローム / 脂肪細胞 / マクロファージ / PPAR-γ / サイトカイン / 肺高血圧 / ホスホリパーゼA2 |
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| Research Abstract |
The effects of abdominal vibration were examined using obese mice with high-fat diet. Daily exposure of the 30-minutes-vibration induced downregulation of adipogenic factors and upregulation of anti-adipogenic factor, which consisted with decreasing adipose tissue triglyceride, some adipokines, and plasma free fatty acids. Furthermore, augmented expressions of several genes characteristic of anti-inflammatory M2 macrophages (Mφ) were detected. The effects of selective sPLA2 inhibitor (indoxam) on the pathogenicity of MCT-induced fatal pulmonary hypertensive rats (MCT-PHR) were also examined. Indoxam abolished the enhanced contractilities of the pulmonary arteries of MCT-PHR, which arteries show augmented expression of sPLA2-X isoform. In addition, administration of indoxam attenuated some inflammatory signs such as expression of proinflammatory cytokines and apoptosis in the lung, leading to a significant improvement of survival ratio in MCT-PHR.
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[Journal Article] Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch2011
Author(s)
Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Ito H
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Journal Title
Science Signaling
Volume: 4
Pages: ra3
DOI
Peer Reviewed
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