2012 Fiscal Year Final Research Report

Stretch of muscle sarcomere induces protrusion of myosinheads toward actin so as to facilitate formation of contractile cross-bridges.

Research Project

Project/Area Number	22616008
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Mechanobiology
Research Institution	Jikei University School of Medicine
Principal Investigator	TAKEMORI Shigeru 東京慈恵会医科大学, 医学部, 教授 (20179675)
Co-Investigator(Kenkyū-buntansha)	YAMAGUCHI Maki 東京慈恵会医科大学, 医学部, 講師 (30271315) KIMURA Masako 女子栄養大学, 栄養学部, 准教授 (30328314)
Co-Investigator(Renkei-kenkyūsha)	OHNO Tetsuo 東京慈恵会医科大学, 医学部, 助教 (30233224)
Research Collaborator	NAKAHARA Naoya 東京慈恵会医科大学, 医学部, 助教 (10632193)
Project Period (FY)	2010 – 2012
Keywords	横紋筋 / エックス線回折 / 収縮
Research Abstract	Stretch of sarcomeres of striated muscle induces higher contractile activity in striated muscle. Well organized fine structure of sarcomere is responsible to this stretch activation phenomenon, but its detailed mechanism has not been elucidated. Developing two-dimensional x-ray diffraction techniques, we found that stretch induces protrusion of myosin heads out of the thick filament backbone toward the neighboring actin molecules on thin filament so as to facilitate formation of contractile cross-bridges between myosin heads and actin molecules.

(4 results)