2012 Fiscal Year Final Research Report
Discrete Model-Based Methods for Control of Complex BiologicalSyetems
| Project/Area Number |
22650045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Sensitivity informatics/Soft computing
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 複雑生体ネットワーク / ブーリアンネットワーク / スケールフリーネットワーク / 遺伝子ネットワーク / 代謝ネットワーク / 制御理論 |
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| Research Abstract |
We performed studies on analysis and control of complex biological networks from various viewpoints. In particular, we developed algorithms for detecting a singleton attractor and a periodic attractor in certain kinds of Boolean networks, clarified the computational hardness of control of probabilistic Boolean networks, developed an approximate method to derive distribution of the number of reactions impacted by knockout of a single reaction, developed a method for network completion using dynamic programming and least-squares fitting, and analyzed structural controllability of complex networks using the concept of the minimum dominating set in graph theory.
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