2011 Fiscal Year Final Research Report
Gene transfer techniques for study of songbird brain circuit
| Project/Area Number |
22650064
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto University |
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Principal Investigator |
WATANABE Dai 京都大学, 大学院・生命科学研究科, 教授 (90303817)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ソングバード |
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| Research Abstract |
Avian species have provided an attractive model system to explore the development and function of brain circuits. Electroporation-mediated and retrovirus(including lentivirus) vector-mediated gene transfer techniques have so far widely been used for introducing genetic material into avian cells. However, it is still challenging to efficiently transduce avian postmitotic neurons without harming the cells. To overcome this problem, we searched a virus vector suitable for gene transfer into avian neurons, and characterize a novel recombinant virus vector, avian adeno-associated virus(A3V) vector.
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Research Products
(17 results)
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[Journal Article] miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression2011
Author(s)
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Uneo S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, KondoM, Yamashita T, Furukawa T
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Journal Title
Nat Neurosci
Volume: 14
Pages: 1125-1134
DOI
Peer Reviewed
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