2011 Fiscal Year Final Research Report
Challenges to elucidate the role of ocular dominance columns for visual perception and to progress the study of OD plasticity in mouse
| Project/Area Number |
22650068
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
TOMITA Koichi 生理学研究所, 行動・代謝分子解析センター, 特任助教 (80314285)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子・細胞神経科学 / 神経可塑性 |
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| Research Abstract |
The aim of this project is elucidating the role of ocular dominance(OD) columns during the depth perception. The mouse, devoid of OD columns, is normally weak in discriminating the visual distance. We originally found that a short form of molecular chaperone, which has a neurite-promoting activity, showed specific expression to the ipsilateral OD columns of the developing visual cortex in higher mammals. To directly test the role of OD columns in the depth perception, I am now investigating whether overexpression of ispilateral OD column-specific chaperone can induce OD columns in mouse visual cortex and, moreover, whether this mouse can show increased ability to discriminate the visual distance.
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[Journal Article] Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats2012
Author(s)
Zhang GX, Obata K, Takeshita D, Mitsuyama S, Nakashima T, Kikuta A, Hirabayashi M, Tomita K, Vetter R, Dillmann WH, Takaki M.
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Journal Title
J Physiol Sci.
Volume: Vol.62, No.3
Pages: 221-231
Peer Reviewed
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[Journal Article] Epigenetic regulation of Kiss1 gene expression mediating estrogen positive feedback action in the mouse brain2012
Author(s)
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda K, Tsukamura H
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Journal Title
Proc. Natl. Acad. Sci.
Volume: Vol.109, No.20
Pages: E1294-1301
Peer Reviewed
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