2011 Fiscal Year Final Research Report
Mechanisms underlying a failure of Neuro-Endocrine-Immune system by chronic stress.
| Project/Area Number |
22650072
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nagoya University (2011)
Osaka City University (2010) |
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Principal Investigator |
KIYAMA Hiroshi 名古屋大学, 大学院・医学系研究科, 教授 (00192021)
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| Co-Investigator(Renkei-kenkyūsha) |
OGAWA Tokiko (30382229)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 解剖学 / 下垂体 / 疲労 / ストレス / 内分泌 / 自律神経 |
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| Research Abstract |
Stress is a common aspect of modern life and plays a role in the etiology of many diseases such as chronic fatigue syndrome(CFS) and fibromyalgia(FM). In this research project we attempted to analyze disorders of Neuro-Endocrine-Immune associated organs from molecular and morphological basis. We identified many changes in expression of molecules in pituitary gland and intriguingly most of expressions were elicited by hypothalamic changes such as alterations of expression of releasing hormones. This suggests that changes of neuronal activity and molecular expressions in hypothalamus due to a prolonged stress could affect neuroendocrine system as well as autonomic system, which lead to a failure of integrity of Neuro-Endocrine-Immune systems.
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