2011 Fiscal Year Final Research Report
Development of anti-tauopathy drugs using C. elegans.
| Project/Area Number |
22650074
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | タウ / タウオパチー / アルツハイマー病 / 神経細胞死 / 線虫 |
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| Research Abstract |
Tauopathy is a category of neurodegenerative disease, which develops tau accumulation in the affected neurons. Because the mechanisms of neurodegeneration of tauopathy remain obscure, screening of anti-tauopathy compounds must be processed using in vivo model, which can assess the neuronal dysfunction affected by abnormal tau. Purposes of this study are 1, to develop the in vivo drug screening system that combines C. elegans model of tauopathy and fluorescence based motion tracking(FMT) system, and 2, to perform direct screening of the anti-tauopathy compounds possibly ameliorate tau-induced neuronal dysfunction using the C. elegans models.
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