2012 Fiscal Year Final Research Report
Rejuvenation of microcirculation in aged rats by young hematopoietic cell transplantation
| Project/Area Number |
22650075
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人先端医療振興財団 (2012)
National Cardiovascular Center Research Institute (2010-2011) |
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Principal Investigator |
TAGUCHI Akihiko 公益財団法人先端医療振興財団, 再生医療研究部, 部長 (10359276)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管再生 / 造血系幹細胞 / 老化 / 若返り / 脳梗塞 / 腎障害 / 骨髄単核球 / Tie2 |
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| Research Abstract |
Circulating bone marrow-derived immature cells have been implicated in homeostasis of the microvasculature, and decreased levels of circulating endothelial progenitor cells, associated with aging, correlate with poor clinical outcomes in a range of cardiovascular diseases. We transplanted bone marrow cells from young stroke-prone spontaneously hypertensive rats (SHR-SP) into aged SHR-SP, and found that animals transplanted with bone marrow from young SHR-SP displayed an increase in density of the microvasculature in the periinfarction zone, reduced ischemic brain damage and improved neurologic function.
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