2011 Fiscal Year Final Research Report
Mapping of the developmental stages of neurons in the brain using the radiosensitivity as an index.
| Project/Area Number |
22650076
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Gunma University |
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Principal Investigator |
SHIRAO Tomoaki 群馬大学, 大学院・医学系研究科, 教授 (20171043)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Nobuhiko 群馬大学, 大学院・医学系研究科, 准教授 (80215251)
HANAMURA Kenji 群馬大学, 大学院・医学系研究科, 助教 (40361365)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 成熟脳神経細胞分化 / 放射線 / 神経細胞移動 / アクチン / ドレブリン / ダブルコルチン |
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| Research Abstract |
Hemispheres of 10-week-old rat brains were irradiated by 10-Gy Xray. Then after two days, we analyzed immunohistochemically the newly-generated migrating neurons to find whether they were survived in the rostral migratory stream from the subventricular zone to the olfactory bulb or to the piriform cortex, and in the hippocampal dentate gyrus. Consequently it was suggested that the radiosensitivity of neurons were determined in an all-or-none manner when those before and after an certain developmental stages were compared with each other. Although this result further had suggested that the decrease of the cell number after the irradiation might be used as an index of the developmental stage of each neuron, it was difficult to be accomplished until the migrating speed of neurons would be clarified.
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[Journal Article] Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons2010
Author(s)
Kaminuma T, Suzuki Y, Shirai K, Mizui T, Noda S, Yosida Y, Funayama T, Takahasi T, Kobayashi Y, Shirao T, Nakano T
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Journal Title
J. Rad. Res
Volume: 51
Pages: 627-631
Peer Reviewed
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