2012 Fiscal Year Final Research Report
Development of cryoprotectant for human cell
| Project/Area Number |
22650114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Chiba University |
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Principal Investigator |
OSUGA Toshiaki 千葉大学, フロンティアメディカル工学研 究開発センター, 准教授 (80223816)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 造血幹細胞 / 血液病 / DMSO / 臍帯血 / 凍害 |
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| Research Abstract |
In order to prevent freezing damage for the hematopoietic stem cell, a cryoprotectant DMSO was added. Since side effects are caused by DMSO, a new cryoprotectant was developed. The ability of the new cryoprotectant is not inferior to that of DMSO since the number of the colonies generated by the hematopoietic stem cell where freezing preservation is carried out using the new cryoprotectant is equivalent to the case using DMSO. Since harmful molecules were not produced in the body of a rat, the toxicity of the new cryoprotectant is expected to be low.
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