2012 Fiscal Year Final Research Report
Etiology and pathophysiology of experimental heterotopic ossification in the spinal cord injury model mouse
| Project/Area Number |
22650126
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
KAWAMURA Morio 名古屋大学, 医学系研究科(保健), 教授 (30186150)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 異所性骨化 / 骨形成因子 / 脊髄損傷 / 動物モデル |
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| Research Abstract |
For the purpose of clarification of patho-physiology of heterotopic ossification, we investigated the state of new bone formation, which was induced by bone morphogenetic protein, in the spinal cord injury model mouse. In the spinal cord injury mouse group, the more significant new bone formation was recognized than in the no injury mouse group. There was no difference in new bone formation between the complete and incomplete spinal cord injury mouse group. When we imposed passive enforced flexion and extension movement on the knee joint of spinal cord injury mouse, the heavy enforcement group showed more volume of new bone formation than no passive movement group. There was no difference of new bone formation between heavy and light enforcement group. And also there was no difference of new bone formation between light enforcement group and no passive movement group. In the patho-histological study, the dense inflammatory reaction was recognized around the bone morphogenetic protein powder in the early phase of implantation. It was suggested the spinal cord injury, enforced passive movement and inflammatory reaction influenced on the etiology of heterotopic ossification.
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