2012 Fiscal Year Final Research Report
Development of a Method to Evaluate the Effects of Rehabilitation on Patients with Spinocerebellar Degeneration Using a Mouse Model of Cerebellar Ataxia
| Project/Area Number |
22650132
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Fujita Health University |
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Principal Investigator |
BEPPU Hidehiro (BEPPU Hidehiko) 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (30142582)
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| Co-Investigator(Kenkyū-buntansha) |
SINZATO Masanori 藤田保健衛生大学, 医療科学部, 准教授 (80148288)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUTANI Kenmei 藤田保健衛生大学, 藤田記念七栗研究所, 助教 (30351068)
YAMAGUCHI Kumiko 藤田保健衛生大学, 藤田記念七栗研究所, 技術員 (50526308)
TAKAHASHI Hisahide 藤田保健衛生大学, 名誉教授 (80084606)
SONODA Sigeru 藤田保健衛生大学, 医学部, 教授 (10197022)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脊髄小脳変性疾患 / 疾患モデルマウス / 小脳失調 / 運動失調 / リハ訓練 / 運動負荷 / B6-wob/t マウス / 生体成分分析 |
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| Research Abstract |
The mouse model developed in this study may be applicable to patients with spinocerebellar degeneration (SCD) involving motor ataxia due to cerebellar Purkinje cell degeneration. Appropriate methods of rehabilitation for SCD patients to improve their motor functions have not yet been established, and, therefore, priority is given to the maintenance of functions other than the spinocerebellar system at present. Considering such a situation, in the study, the mouse was treated with simulation rehabilitation training, and a rotarod test was subsequently performed to evaluate its balance ability and coordinated movements in comparison with those without training. As a result, training with exercise improved the mouse’s coordinated movements, suggesting thatcontinuous gait training may reduce SCD patients’ staggering gait.
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[Presentation] Development of human serum proteomics.2012
Author(s)
Ken Hirosaki, Hidehiko Beppu, Lumi Negishi, Paxton Thanai, Takayuki Yonezawa, Shigeru Sonoda, Ung-il Chung, Nobuhiro Hayashi
Organizer
The 85th Annual Meeting of the Japanese Biochemical Society
Place of Presentation
Fukuoka, Japan.
Year and Date
20121214-16
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