2012 Fiscal Year Final Research Report
Effects of medullary raphe nuclei lesions during developmental stageon sleep
| Project/Area Number |
22650141
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical education
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Satoshi 鳥取大学, 医学部, 准教授 (40219390)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 身体システム学 / 延髄縫線核 |
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| Research Abstract |
Midline raphe nuclei of the brainstem have been implicated in motor function, sensory processing, autonomic neural control systems and memory. They have also played an important role in sleep. The present study was undertaken to investigateeffects of kainic acid injection into the medullary raphe nuclei of young and adult raton respiration. We also examined effect of the lesion during development on sleep.The chemical lesions of adult rat induced a transient increase in frequency of respiration, and the frequency subsequently decreased. Then, apnea was elicited. After the lesion of the medullary raphe nuclei during developing periods, the rats had light sleep compare to normal adult rats. These results suggest that lesions of medullary raphe nuclei by kainic acid change respiratory movement. Medullary raphe lesionsduring developing periods in rats also affect sleep patterns
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