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2011 Fiscal Year Final Research Report

Involvement of cytoglobin-expressing mesenchymal cells in cancer development

Research Project

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Project/Area Number 22650224
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Carcinogenesis
Research InstitutionOsaka City University

Principal Investigator

KAWADA Norifumi  大阪市立大学, 大学院・医学研究科, 教授 (30271191)

Co-Investigator(Kenkyū-buntansha) LE Thuy  大阪市立大学, 大学院・医学研究科, 博士研究員 (10572175)
OGAWA Tomohiro  大阪市立大学, 大学院・医学研究科, 博士研究員 (70448752)
MOTOYAMA Hiroyuki  大阪市立大学, 大学院・医学研究科, 医員 (00573601)
Project Period (FY) 2010 – 2011
Keywordsサイトグロビン / ビタミンA / 乳癌 / 線維芽細胞 / 自然発症 / 間質細胞
Research Abstract

Incidence of breast cancer has been increasing in developed countries including Japan and has become a world-wide health problem. To clarify the molecular function of cytoglobin(Cygb) in vivo, we generated Cygb-deficient mice. Surprisingly, we observed the spontaneous development of breast cancer and lymphoma in Cygb-deficient female mice at high incidence compared to the negligible detection of such tumors in wild-type mice. Based on these findings, we studied the molecular events leading to breast cancer development in Cygb-deficiency with special regards to the interaction between epithelial cells and mesenchymal cells.

  • Research Products

    (16 results)

All 2012 2011 2010 Other

All Journal Article (12 results) Presentation (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Antifibrotic role of macrophage migration inhibitory factor : discovery of an unexpected function. Thuy le TT2012

    • Author(s)
      Kawada N.
    • Journal Title

      Hepatology

      Volume: 55 Pages: 1295-7

  • [Journal Article] Inflammation and fibrogenesis in steatohepatitis2012

    • Author(s)
      Fujii H, Kawada N.
    • Journal Title

      J Gastroenterol

      Volume: 47 Pages: 215-25

  • [Journal Article] N-Acetylglucosaminyltransferase V regulates TGF-βresponse in hepatic stellate cells and the progression of steatohepatitis2012

    • Author(s)
      Kamada Y, Mori K, Matsumoto H, Kiso S, Yoshida Y, Shinzaki S, Hiramatsu N, Ishii M, Moriwaki K, Kawada N, Takehara T, Miyoshi E.
    • Journal Title

      Glycobiology

      Volume: 22 Pages: 778-87

  • [Journal Article] MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis2012

    • Author(s)
      Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N
    • Journal Title

      Gut

      Volume: (in press)

  • [Journal Article] Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway2012

    • Author(s)
      Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J.
    • Journal Title

      Lab Invest

      Volume: 92 Pages: 57-71

  • [Journal Article] Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation2011

    • Author(s)
      Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N.
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 2535-42

  • [Journal Article] Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Thuy le TT2011

    • Author(s)
      Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N.
    • Journal Title

      Am J Pathol

      Volume: 179 Pages: 1050-60

  • [Journal Article] Cytoglobin expression of rectal subepithelial myofibroblasts : significant alterations of cytoglobin+stromal cells in long-standing ulcerative colitis2011

    • Author(s)
      Okayasu I, Mikami T, Yoshida T, Hana K, Yokozawa M, Sada M, Fujiwara M, Kawada N.
    • Journal Title

      Histol Histopathol

      Volume: 26 Pages: 679-88

  • [Journal Article] Evolution of hepatic fibrosis research2011

    • Author(s)
      Kawada N.
    • Journal Title

      Hepatol Res

      Volume: 41 Pages: 199-208

  • [Journal Article] Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions2011

    • Author(s)
      Nishi H, Inagi R, Kawada N, Yoshizato K, Mimura I, Fujita T, Nangaku M.
    • Journal Title

      Am J Pathol

      Volume: 178 Pages: 128-39

  • [Journal Article] A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits2010

    • Author(s)
      Ogawa T, Fujii H, Yoshizato K, Kawada N.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 153-65

  • [Journal Article] Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development2010

    • Author(s)
      Spector I, Honig H, Kawada N, Nagler A, Genin O, Pines M.
    • Journal Title

      Pancreas

      Volume: 39 Pages: 1008-15

  • [Presentation] Cytoglobin as a novel tumor suppressor in the liver2011

    • Author(s)
      Kawada N
    • Organizer
      Le TT. AASLD
    • Place of Presentation
      サンフランシスコ、USA
    • Year and Date
      2011-11-04
  • [Presentation] Promotion of liver and lung tumorgenesis in DEN-treated cytoglobin-deficient mice2011

    • Organizer
      16^<th> International Symposium on Cells of the Heatic Sinusoid
    • Place of Presentation
      イタリア、フロレンス
    • Year and Date
      2011-09-23
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/syoukaki/hepatology/index.html

  • [Patent(Industrial Property Rights)] サイトグロビン遺伝子ノックアウト非ヒト癌モデル動物2010

    • Inventor(s)
      河田則文
    • Industrial Property Rights Holder
      河田則文
    • Industrial Property Number
      特願、2010-052244
    • Filing Date
      2010-03-09

URL: 

Published: 2013-07-31  

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