2011 Fiscal Year Final Research Report
Molecular mechanism of auto-translocation of membrane anchored EGFR ligand into the nuclear membrane and its diagnostic application of cancer
| Project/Area Number |
22650228
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDA Shinji 愛媛大学, 医学系研究科, 助教 (70398238)
SAWASAKI Tatsuya 愛媛大学, 無細胞生命科学工学研究センター, 准教授 (50314969)
JOH Takashi 名古屋市立大学, 医学系研究科, 教授 (30231369)
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| Project Period (FY) |
2010 – 2011
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| Keywords | がん細胞の特性 |
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| Research Abstract |
HB-EGF and AREG are synthesized as a membrane-anchored growth factor and expressed at the plasma membrane as pro-forms in normal cells. In some malignant tumor cells in culture, however, proHB-EGF and proAREG trans-locate at the ER/nuclear membrane, which endows resistance for anti-cancer drugs. In this study, we established mouse models bearing tumor expressing proAREG auto-translocation mutant, and showed that the tumor acquired resistance for chemotherapy in vivo. We also tried to identify C-terminal processing proteases of proHB-EGF and proAREG.
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Research Products
(17 results)
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[Journal Article] TGFβinduces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells2010
Author(s)
Ebi M, Kataoka H, Shimura T, Kubota E, Hirata Y, Mizushima T, Mizoshita T, Tanaka M, Mabuchi M, Tsukamoto H, Tanida S, Kamiya T, Higashiyama S, Joh T.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 1402
Pages: 449-454
Peer Reviewed
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