2011 Fiscal Year Final Research Report
Developing a model predicting toxicities of metal mixture
| Project/Area Number |
22651011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental impact assessment/Environmental policy
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
KAMO Masashi 独立行政法人産業技術総合研究所, 安全科学研究部門, 研究員 (90415662)
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| Co-Investigator(Kenkyū-buntansha) |
TADA Mitsuru 独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (00188252)
NAGAI Takashi 農業環境技術研究所, 有機化学物質研究領域, 研究員 (10391129)
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| Project Period (FY) |
2010 – 2011
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| Keywords | Biotic Ligand Model / 重金属 / 複合毒性 / 生態リスク評価 |
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| Research Abstract |
A Biotic Ligand Model(BLM) predicting toxicities of metal mixtures was developed. We conducted toxicity tests of copper, zinc and cadmium using algae, and zinc and copper using daphnia. We first determined the half effect concentrations of single metals, and then conducted mixture tests. We calibrated model parameters for algae, and found that the developed model well predicted the toxicity of metal mixtures. Whereas, in the case of daphnia, the predictability of the model was less accurate. The failure of the prediction may be attributed to the use of model parameters determined by previous toxicity tests conducted in the different test medium with different water quality. A refining of the model parameters suitable to our tests medium may be necessary, but is remaining as a future study.
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