2011 Fiscal Year Final Research Report
Epigenetic regulation by selenoproteins
| Project/Area Number |
22651070
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Genome biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HIROSAWA Mitsuko 東京大学, 大学院・農学生命科学研究科, 特任准教授 (60533982)
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| Project Period (FY) |
2010 – 2011
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| Keywords | エピゲノム / セレノプロテイン |
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| Research Abstract |
In this study, we showed that SelH, the only nuclear protein in the selenoprotein family, can bind to specific gene regions on the genome in ES cells to control the epigenetic state of some pluripotency-related genes. Until today, it has been only focused in the antioxidant activity as a function of the selenoprotein. However, there is a new aspect that selenoprotein has the function involved in epigenetic regulation. Since selenoproteins contain selenium as selenocystein, we proposed the importance of the selenium from the epigenetic prospective, as well as nutritional and environmental point of view.
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[Journal Article] Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance2011
Author(s)
Shchedrina VA, Kabil H, Vorbruggen G, Lee BC, Turanov AA, Hirosawa-Takamori M, Kim HY, Harshman LG, Hatfield DL and Gladyshev VN
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Journal Title
J Biol Chem
Volume: 286(34)
Pages: 29449-29461
DOI
Peer Reviewed
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