2011 Fiscal Year Final Research Report
Challenge for Detoxification of Arsenic by Methylated Metal Complex
| Project/Area Number |
22655018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Inorganic chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Masaaki 九州大学, 大学院・工学研究院, 准教授 (90260033)
SHIMAKOSHI Hisashi 九州大学, 大学院・工学研究院, 助教 (00284539)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 金属錯体化学 / 無機ヒ素 / メチル化反応 / ビタミンB_<12> / グルタチオン / チオール / コバルト錯体 |
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| Research Abstract |
Inorganic arsenic has caused serious chronic diseases throughenvironmental pollution. However, some methylated arsenic compounds, especiallytrimethylarsine oxide(TMAO) and arsenobatetaine(AB) have much lower toxicities thanarsenic trioxide(As2O3). The acute toxicity of AB, as determined from animal experiments, is approximately one three-hundredth of that of arsenic trioxide. Meanwhile, in marineecosystems, inorganic arsenicals are biologically methylated through the food chain, whichinvolves a methyltransferase and a reductase. An interesting application of the methyltransfer reaction with vitamin B_<12> to the detoxification system for inorganic arsenic hasbeen succeeded. This is a new and selective detoxification method for inorganic arsenic, which is the biomimetic methylation of arsenic trioxide(As2O3) to give trimethylarsineoxide(TMAO).
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