2011 Fiscal Year Final Research Report
Asymmetric Control of Conjugated Umpolung by the Combination of a Cyclophane-Type N-Heterocyclic Carbene and a Ketone
| Project/Area Number |
22655024
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kochi University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 触媒的不斉合成 / カルベン触媒 / ケトン助触媒 / 極性変換反応 / 自己環化反応 / ラクトン合成 / シクロファン |
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| Research Abstract |
We discovered a new asymmetric reaction(self-annulation of 2-alkenals) by using an organocatalyst, which has been developed by our group. It is curious that the use of an organic co-catalyst is essential for the reaction. Upon studying the reaction in detail, we proposed a plausible reaction mechanism. The reaction will be useful, because the products have a fundamental skeleton, which is widely found in bio-active compounds.
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