2012 Fiscal Year Final Research Report
Development of Oxidative Cyclization Reactions via C-H CleavageBased on First Row Transition Metal Catalysts
| Project/Area Number |
22655027
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
MIURA Masahiro 大阪大学, 大学院・工学研究科, 教授 (20183626)
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| Co-Investigator(Renkei-kenkyūsha) |
SATOH Tetsuya 大阪大学, 大学院・工学研究科, 准教授 (40273586)
HIRANO Koji 大阪大学, 大学院・工学研究科, 助教 (70532696)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 有機合成化学 / 有機金属化学 / 銅 / 分子状酸素 / 酸化カップリング・アミノ化 / アリール化 / 炭素-水素結合直接変換 |
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| Research Abstract |
We have focused on the potential of first row transition metals, in particular, copper salts, and succeeded in the development of unique catalytic activity of copper/O2systems. Namely, the copper-catalyzed oxidative direct cyclization between N-methylanilines and electron-deficient olefins proceeded through C-H cleavage even under ambient conditions. In addition, when a similar copper/oxygen catalyst was applied to the reaction of heteroarenes with sulfoximines, the direct C-N bond formation occurred via both C-H and C-N cleavages.
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