2012 Fiscal Year Final Research Report
Experimental investigation on the origination of centromeres from telomeres
| Project/Area Number |
22657002
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
ISHII Kojiro 大阪大学, 生命機能研究科, 特任准教授 (40360276)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ゲノム / テロメア / セントロメア / 染色体 |
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| Research Abstract |
Centromeres and telomeres are the two specialized chromatin domains both serving for stable chromosome inheritance. Intriguingly, their location and functionality often change simultaneously in the course of chromosome evolution. We experimentally analyzed such an interrelationship, if any, between centromeres and telomeres. We found that de novo centromere formation stimulated by centromere dysfunction requires the telomere as a domain located at the end of chromosomes, which is mediated by telomeric heterochromatin and the other factors.
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