2011 Fiscal Year Final Research Report
Search for metabolic oscillator regulating food anticipatory activity
| Project/Area Number |
22657020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脳・神経 / 摂餌 / サーカディアンリズム / 動物行動 / 時計遺伝子 / 視床下部 / 体内時計 / CRY |
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| Research Abstract |
Food anticipatory activities(FAA) are known to be induced by temporal restriction of feeding, and are regulated by a food-entrainable oscillator(FEO) located in the brain. One of the most important issues in this field is the localization of FEO and the molecular mechanisms of FEO. In this study, we developed an automated feeding apparatus that enables us to control the restricted feeding timing. Furthermore, we focused our attention to MBH as the brain region of FEO, and identified restricted-feeding response genes by microarray analysis of the MBH. The result should be valuable for approaching the molecular mechanisms of FEO.
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