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2011 Fiscal Year Final Research Report

Screening and analysis of genes involved in regulation of lysosomal dynamics

Research Project

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Project/Area Number 22657032
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionThe University of Tokyo

Principal Investigator

KONTANI Kenji  東京大学, 大学院・薬学系研究科, 准教授 (30302615)

Project Period (FY) 2010 – 2011
Keywordsリソソーム / 膜オルガネラ / 膜輸送 / 線虫 / Gタンパク質 / RNAi
Research Abstract

Lysosomes are membrane organelles responsible for degradation of various macromolecules. Fusion of lysosomes with other membrane organelles is critical for the lysosomal degradation ; however, the molecular mechanism underlying the lysosomal fusion is poorly understood. In the present study, I performed genetic screening for genes involved in regulation of lysosomal dynamics using the nematode C. elegans as a model organism and found that the small GTPase Arl8 may cooperatively function with the HOPS complex to regulate lysosomal fusion.

  • Research Products

    (19 results)

All 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK72011

    • Author(s)
      Takahashi, S., Ebihara, A., Kajiho, H., Kontani, K., Nishina, H., and Katada, T.
    • Journal Title

      Cell Death Differ

      Volume: 18 Pages: 645-655

    • DOI

      DOI:10.1038/cdd.2010.137

    • Peer Reviewed
  • [Journal Article] cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites2011

    • Author(s)
      Saito, K., Yamashiro, K., Ichikawa, Y., Erlmann, P., Kontani, K., Malhotra, V., and Katada, T.
    • Journal Title

      Mol Biol Cell

      Volume: 22 Pages: 2301-2308

    • DOI

      DOI:10.1091/mbc.E11-02-0143

    • Peer Reviewed
  • [Journal Article] Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab312011

    • Author(s)
      Kajiho, H., Sakurai, K., Minoda, T., Yoshikawa, M., Nakagawa, S., Fukushima, S., Kontani, K., and Katada, T.
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 24364-24373

    • DOI

      DOI:10.1074/jbc.M110.172445

    • Peer Reviewed
  • [Journal Article] RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs2011

    • Author(s)
      Takahashi, S., Sakurai, K., Ebihara, A., Kajiho, H., Saito, K., Kontani, K., Nishina, H., and Katada, T.
    • Journal Title

      Nucleic Acids Res

      Volume: 39 Pages: 3446-3457

    • DOI

      DOI:10.1093/nar/gkq1302

    • Peer Reviewed
  • [Journal Article] The Arf-like GTPase Arl8 Mediates Delivery of Endocytosed Macromolecules to Lysosomes in Caenorhabditis elegans2010

    • Author(s)
      Nakae, I., Fujino, T., Kobayashi, T., Sasaki, A., Kikko, Y., Fukuyama, M., Gengyo-Ando, K., Mitani, S., Kontani, K., and Katada, T.
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 2434-2442

    • DOI

      DOI:10.1091/mbc.E09-12-1010

    • Peer Reviewed
  • [Journal Article] An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation2010

    • Author(s)
      Klassen, M. P., Wu, Y. E., Maeder, C. I., Nakae, I., Cueva, J. G., Lehrman, E. K., Tada, M., Gengyo-Ando, K., Wang, G. J., Goodman, M., Mitani, S., Kontani, K., Katada, T., and Shen, K.
    • Journal Title

      Neuron

      Volume: 66 Pages: 710-723

    • DOI

      DOI:10.1016/j.neuron.2010.04.033

    • Peer Reviewed
  • [Journal Article] Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans2010

    • Author(s)
      Cevik, S., Hori, Y., Kaplan, O. I., Kida, K., Toivenon, T., Foley-Fisher, C., Cottell, D., Katada, T., Kontani, K., and Blacque, O. E.
    • Journal Title

      J Cell Biol

      Volume: 188 Pages: 953-969

    • DOI

      DOI:10.1083/jcb.200908133

    • Peer Reviewed
  • [Presentation] マルチドメイン型RabファミリーG蛋白質EFCAB4Baの機能解析2011

    • Author(s)
      阿部芙美子, 他
    • Organizer
      ファーマ・バイオフォーラム2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-08
  • [Presentation] リソソームへの輸送における低分子量Gタンパク質Arl8の機能解析2011

    • Author(s)
      紺谷圏二, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
  • [Presentation] The ciliary small GTPaseArl13b(I): Arl13b functions at ciliarymembranes and stabilizes intraflagellartransport2011

    • Author(s)
      堀裕次, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
  • [Presentation] The ciliary small GTPase Arl13b(II): Arl13b functions at ciliary membranes and stabilizes intraflagellar transport2011

    • Author(s)
      永島慎一, 他
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
  • [Presentation] Arf-like GTPaseが介在する細胞内ロジスティクスと関連疾患2011

    • Author(s)
      紺谷圏二, 他
    • Organizer
      文部科学省科学研究費補助金新学術領域研究第3回「細胞内ロジスティクス」班会議
    • Place of Presentation
      鳥羽
    • Year and Date
      2011-06-03
  • [Presentation] Functional analysis of the ciliary small GTPase Arl13b2010

    • Author(s)
      堀裕次, 他
    • Organizer
      The 3rd Global COE Retreat
    • Place of Presentation
      幕張
    • Year and Date
      2010-12-11
  • [Presentation] 線虫C. elegansを用いた低分子量Gタンパク質Ragの機能解析2010

    • Author(s)
      壹岐和哉, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] 線虫C. elegansを用いたアミノ酸シグナル伝達に介在する低分子量G蛋白質Ragの機能解析2010

    • Author(s)
      伊藤有佳子, 他
    • Organizer
      ファーマ・バイオフォーラム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-10-02
  • [Presentation] 低分子量Gタンパク質Arl13bの繊毛局在化メカニズムの解析2010

    • Author(s)
      永島慎一, 他
    • Organizer
      ファーマ・バイオフォーラム2010
    • Place of Presentation
      京都
    • Year and Date
      2010-10-02
  • [Presentation] リソソームの機能制御に介在する低分子量G蛋白質Arl8の解析2010

    • Author(s)
      紺谷圏二, 他
    • Organizer
      第9回生命科学研究会
    • Place of Presentation
      筑波
    • Year and Date
      2010-06-25
  • [Presentation] Foxo and RagA link multiple stem cell lineages to coordinate somatic development in C. elegans2010

    • Author(s)
      福山征光, 他
    • Organizer
      第43回日本発生生物学会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-21
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~seiri

URL: 

Published: 2013-07-31  

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