2012 Fiscal Year Final Research Report
Analyses on the nuclear structures regulating the alternative splicingspatiotemporally using bioprobes
| Project/Area Number |
22657050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TANI Tokio 熊本大学, 大学院・自然科学研究科, 教授 (80197516)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 遺伝子発現制御 / 核内構造 / 選択的スプライシング / mRNA 核外輸送 / バイオプローブ |
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| Research Abstract |
In eukaryotic cells, the nucleus is highly compartmentalized with dozens of nuclearstructures. Gene expression in the eukaryotic cells is co-ordinately regulated via thosenuclear structures. In this study, we analyzed the mechanisms of the post-transcriptionalregulation of gene expression, such as alternative splicing and nuclear mRNA export,conducted spatiotemporally via the nuclear structures, using the compounds isolated fromcultures of the actinomycetes, which inhibit the formation of the nuclear structures,as biological probes
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[Presentation] Characterization of Natural Compoundsthat Affect Nuclear Speckle Formation andAlternative Pre-mRNA Splicing in MammalianCells2012
Author(s)
Yutaro Kurogi, Yota Matsuo, HiroakiYagi, Yuki Mihara, Haruka Iwamoto, HafizeA. Demirkol, Yamato Kojimoto, Yuya Uehara,Hitoshi Suzuki, Masatoshi Hagiwara,Masayuki Igarashi, and Tokio Tani
Organizer
The 22nd CDB Meeting "RNA Sciences in Cell andDevelopmental Biology II"
Place of Presentation
理研CDB(神戸)
Year and Date
2012-06-13
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[Presentation] Screening and Characterization ofNatural Compounds that Affect NuclearSpeckle Formation and AlternativePre-mRNA Splicing in Mammalian Cells2011
Author(s)
Yota Matsuo, Yutaro Kurogi, Hiroaki Yagi,Yuki Mihara, Haruka Iwamoto, Hafize A.Demirkol, Yamato Kojimoto, Yuya Uehara,Hitoshi Suzuki, Masatoshi Hagiwara,Masayuki Igarashi, and Tokio Tani
Organizer
第34回日本分子生物学会
Place of Presentation
パシフィコ横浜(横浜)
Year and Date
2011-12-15
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