• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Study of mechanosensing in the spindle using a 3D force microscope

Research Project

  • PDF
Project/Area Number 22657051
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionThe University of Tokyo (2011)
Gakushuin University (2010)

Principal Investigator

YAJIMA Junichiro  東京大学, 大学院・総合文化研究科, 准教授 (00453499)

Research Collaborator NISHIZAKA Takayuki  学習院大学, 理学部, 教授 (40359112)
Project Period (FY) 2010 – 2011
Keywords微小管 / 分裂期分子モータータンパク質 / メカノセンサー
Research Abstract

As a cell changes its shape such as cell division, one of the cytoskeletons, a microtubule, is subject to mechanical stress and responds to mechanical stimulation. These responses may regulate biochemical and mechanical reactions in cell. One way to understand its regulated system is to apply mechanical stress to a microtubule in an in vitro assay and then to quantify motility of molecular motors(kinesins and dyneins) interacted with the microtubule. We constructed microscope systems, which are able to apply mechanical force into the microtubule in 3D dimensions. Using this system, we are examining if a microtubule is mechano-sensor.

  • Research Products

    (4 results)

All 2012 2011 2010 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] テトラヒメナ外腕ダイニンによる微小管の滑り回転運動2012

    • Author(s)
      山口真、豊島陽子、矢島潤一郎
    • Organizer
      2012年生体運動研究合同班会議
    • Place of Presentation
      筑波大学、つくば市
    • Year and Date
      20120106-08
  • [Presentation] キネシンモーターによる微小管の並進回転運動メカニズム2011

    • Author(s)
      矢島潤一郎、西坂孝之、Robert Cross
    • Organizer
      2011年生体運動研究合同班会議
    • Place of Presentation
      大阪市立大学、大阪市
    • Year and Date
      20110107-09
  • [Presentation] Characterising the corkscrew motion of a microtubule driven by single-headed kinesins2010

    • Author(s)
      矢島潤一郎、西坂孝之
    • Organizer
      Actin, the Cytoskeleton and the Nucleus. Mechanobiology workshop
    • Place of Presentation
      シンガポール国立大学、シンガポール
    • Year and Date
      20101109-12
  • [Remarks]

    • URL

      http://bio.c.u-tokyo.ac.jp/laboratories/yajima.html

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi