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2011 Fiscal Year Final Research Report

Evaluation of a hypothesis that "The intestinal detoxification system can be regulated by eating"

Research Project

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Project/Area Number 22658040
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMIZU Makoto  東京大学, 大学院・農学生命科学研究科, 教授 (30114507)

Project Period (FY) 2010 – 2011
Keywords食品 / 解毒代謝 / 腸管バリア
Research Abstract

Dioxin-induced expression of intestinal detoxification enzymes(DTE), such as CYPs, was suppressed by flavonoids. The CYP expression was also induced by certain flavonoids. DNA microarray analysis showed that dioxins and flavonoids caused different gene expression of intestinal DTE. Among eight flavonoids having the AhR agonistic activity, only one of them was able to induce regulatory T cell differentiation via AhR activation, suggesting that a small difference in the AhR/ligand interaction was responsible for the variability of gene expression.

  • Research Products

    (7 results)

All 2012 2011 2010

All Journal Article (2 results) Presentation (5 results)

  • [Journal Article] Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor(AhR)-mediated pathway2012

    • Author(s)
      Wang, H-K., Yeh, C-H., Iwamoto, T., Satsu, H., Shimizu, M., Totsuka, M.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 60(9) Pages: 2171-2178

  • [Journal Article] Metabolites of galangin by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor2010

    • Author(s)
      Hamada, M., Satsu, H., Ashida, H., Sugita-Konishi, Y., Shimizu, M.
    • Journal Title

      J. Agric. Food Chem.

      Volume: 58 Pages: 8111-8118

  • [Presentation] 柑橘類由来ナリンゲニンにより誘導されるマウス制御性T細胞の機能解析2012

    • Author(s)
      王璽凱、葉鎮豪、岩本拓、薩秀夫、清水誠、戸塚護
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      20120322-25
  • [Presentation] Screening and evaluation of dietary arylhydrocarbon receptors(AhR) ligands inducing differentiation of regulatory T cells2011

    • Author(s)
      Wang, H-K., Iwamoto, T., Satsu, H., Shimizu, M., Totsuka, M
    • Organizer
      5th International Conference on Functional Foods
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20111121-23
  • [Presentation] Induction of detoxification enzymes by equol via activation of pregnane X receptor in human intestinal epithelial cells2011

    • Author(s)
      Satsu, H., Mizukami, T., Mikubo, A., Tachibana, N., Wanezaki, S., Kohno, M., Hamada, M., Iwayanagi, C., Ogiwara, H., Shimizu, M
    • Organizer
      5th International Conference on Functional Foods
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      20111121-23
  • [Presentation] Naringeninと食品由来AHRリガンドによるマウス制御性T細胞の誘導機能2011

    • Author(s)
      王璽凱、岩本拓、薩秀夫、清水誠、戸塚護
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      20110325-28
  • [Presentation] ブロッコリースプラウトがAhRに及ぼす影響2010

    • Author(s)
      三久保絢之、薩秀夫、水上朋彦、濱田美影、吉田和敬、牛田悠介、森啓信、稲熊隆博、清水誠
    • Organizer
      日本農芸化学会関東支部2010年度大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-10-09

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Published: 2013-07-31  

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