2011 Fiscal Year Final Research Report
Amelioration of allergosis by new mast cell stabilizer targeting zinc ion signaling.
| Project/Area Number |
22658089
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HORI Masatoshi 東京大学, 大学院・農学生命科学研究科, 准教授 (70211547)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 薬理 |
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| Research Abstract |
In the present study, we established a foundation for a new therapeutic strategy of allergosis of domestic animals and human by using a new zinc ion chelator, IPZ-010, targeting mast cells. In particular, we used mast cells derived post-operative ileus model mice. This animal model can be made in a breeze, in a short period of time, and with high repeatability. Results indicated that IPZ-010 significantly ameliorated inflammation by post-operative ileus with oral or subcutaneous administration via mast cells stabilization.
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