2011 Fiscal Year Final Research Report
Induction of hibernation in the rat, a non-hibernator, and its application to therapy for ischemic injury.
| Project/Area Number |
22658092
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIINA Takahiko 岐阜大学, 応用生物科学部, 准教授 (90362178)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 冬眠 / 低体温 / 心臓 / 虚血性心疾患 / アデノシン / 心電図 / 睡眠 / アデノシンA1受容体 |
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| Research Abstract |
An extreme hypothermic condition would be beneficial for developing new therapies, especially for cancers or reperfusion injury in ischemic diseases. The present study was designed to develop a method for inducing hypothermia, which is equivalent to hibernating animals, in non-hibernators. In rats(non-hibernator), hypothermia forcibly induced by inhalation anesthesia combined with cooling of the animals resulted in cardiac arrest when their body temperatures were dropped around 25℃. In contrast, body temperature of rats can be reduced less than 10℃ when inhalation of the anesthesia was stopped during the cooling process.
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