2011 Fiscal Year Final Research Report
Translational Study For Child Abuse using Mice As Its Animal Model
| Project/Area Number |
22658093
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 行動 / マウス / 児童虐待 / 動物モデル / 脱ユビキチン化酵素 |
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| Research Abstract |
The present study was undertaken to assess the validity of Usp46 mutant mice from behavioral standpoint as an animal model for child abuse in human(Usp46 regulates "behavioral despair" in mice). We examined three features in human child abuse :(1) repetition of abuse,(2) succession of child abuse to next generation,(3) stress-induced child abuse. As a result, we found that Usp46 mutant mice possess these three features.
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