Cruciate injury model and cruciate regeneration with MSC by using of BPR system in micro-mini pig.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22658100
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Clinical veterinary science
• Research Institution: Kagoshima University
• Principal Investigator: FUJIKI Makoto 鹿児島大学, 農学部, 准教授 (60305167)
• Co-Investigator(Kenkyū-buntansha): MISUMI Kazuhiro 鹿児島大学, 農学部, 教授 (10291551) ; NAKAYAMA Kouichi 佐賀大学, 理工学部, 教授 (50420609) ; KAWAGUCHI Hiroaki 鹿児島大学, 農学部, 准教授 (60325777) ; MATSUDA Syuichi 九州大学, 医学部, 講師 (40294938)
• Project Period (FY): 2010 – 2011
• Keywords: 半月板再生

Research Abstract

The tissue regeneration was researched by using micro mini-pig(MMP) with the mesenchymal system cell derived from subcutaneous adipose tissue for meniscus injury model. It was confirmed that the preparation of plug for transplantation with mesenchymal cells derived from subcutaneous fat is possible. However, it was not possible to confirm meniscus regeneration by being not able to maintain the nature of the transplant spheroid for partial deficit model of the MMP. In meniscus and osteochondral defect model without arthrotomy, the effectiveness of knee osteoarthritis as a model was suggested.