2011 Fiscal Year Final Research Report
A novel signal transduction pathway which regulates the structure of P-body and the dynamics of ARE-mRNAs
| Project/Area Number |
22659015
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
KATADA Toshiaki 東京大学, 大学院・薬学系研究科, 教授 (10088859)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAJIHO Hiroaki 東京大学, 大学院・薬学系研究科, 助教 (70401221)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | シグナル伝達 / G蛋白質 / P-body / mRNA動態 |
|---|
| Research Abstract |
Processing bodies(P-bodies) contain a common set of conserved RNA-processing enzymes, and mRNAs with AU-rich elements(AREs) are delivered to P-bodies for translational silencing. It is unclear how small GTPases are involved in the P-body regulation and the ARE-mRNA metabolism. We found here that overexpression of the RhoA-subfamily GTPases alters the P-body dynamics in HeLa cells. Interestingly, both RhoA activation and glucose depletion inhibit the mRNA accumulation and degradation. These findings indicate that RhoA participates in the stress-induced rearrangement of P-bodies and the release of nucleated ARE-mRNAs for their stabilization.
|
Research Products
(24 results)
-
-
-
[Journal Article] Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex2011
Author(s)
Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H.
-
Journal Title
J Neurosci
Volume: 31
Pages: 16872-16883
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] AnArf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation2010
Author(s)
Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K.
-
Journal Title
Neuron
Volume: 66
Pages: 710-723
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
