2011 Fiscal Year Final Research Report
A peptide sequence motif which regulates glycoforms
| Project/Area Number |
22659016
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IRIMURA Tatsuro 東京大学, 大学院・薬学系研究科, 教授 (80092146)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 糖蛋白質 / 正合成 / ゴルジ装置 / ウイルス感染 / 糖鎖 |
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| Research Abstract |
The Ebola virus envelope glycoprotein(GP) determines the infectivity through their differential degree of interaction with MGL, a C-type lectin, and the interaction depends on the carbohydrate structures. Structural determinations of glycans of Zaire GP, Reston GP, and chimeric GPs clearly demonstrated that 18 amino acid residues in the GPs determines the N-glycan extension, particularly transfer of galactose. A possibility that the sequence determines the retention of the glycoprotein at a specific compartment in Golgi apparatus was also shown. Furthermore, importance of specific residues within the 18 amino acids was established.
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[Journal Article] Expression and role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma2011
Author(s)
Kamiyama S, Ichimiya T, Ikehara Y, Takase T, Fujimoto I, Suda T, Nakamori S, Nakamura M, Nakayama F, Irimura T, Nakanishi H, Watanabe M, Narimatsu H, Nishihara S
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Journal Title
Glycobiology
Volume: 21(2)
Pages: 235-246
URL
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[Journal Article] Wisteria floribunda agglutinin-positive mucin 1 is a sensitive biliary marker for human cholangiocarcinoma2010
Author(s)
Matsuda A, Kuno A, Kawamoto T, Matsuzaki H, Irimura T, Ikehara Y, Zen Y, Nakanuma Y, Yamamoto M, Ohkohchi, N, Shoda J, Hirabayashi J, Narimatsu H
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Journal Title
Hepatology
Volume: 52(1)
Pages: 174-182
DOI
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[Journal Article] Different potential of C-type lectin-mediated entry between Marburg virus strains2010
Author(s)
Matsuno K, Kishida N, Usami K, Igarashi M, Yoshida R, Nakayama E, Shimojima M, Feldmann H, Irimura T, Kawaoka Y, Takada A
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Journal Title
J Virol
Volume: 84(10)
Pages: 5140-5147
URL
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