2011 Fiscal Year Final Research Report
Development of nucleic acid antibody with ADCC activity
| Project/Area Number |
22659020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ICHIKAWA Satoshi 北海道大学, 大学院・薬学研究院, 准教授 (60333621)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 有機化学 / 抗がん / 天然物 / 核酸抗体 |
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| Research Abstract |
First total synthesis of quinaldopeptin has been accomplished via solid-phase peptide synthesis. Namely, the linear decapeptide was sequentially cyclized and attached by chromophores to give quinaldopeptin. It was revealed that quinaldopeptin binds to double-stranded DNA with high affinity. Finally, quinaldopeptin was installed to the double-stranded DNA to afford a nucleic acid antibody with ADCC activity.
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Research Products
(18 results)
