2011 Fiscal Year Final Research Report
Mechanism underlying reproductive and developmental toxicity by dioxin : the role of a reduction in prolactin as an initial defect
| Project/Area Number |
22659026
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMADA Hideyuki 九州大学, 薬学研究院・分子衛生薬学分野 (40142351)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 食品衛生学 |
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| Research Abstract |
The role of the damage to maternal prolactin(PRL) and infant growth hormone(GH) in the dioxin-produced retardation of infant growth was investigated in rats. Single oral dose(1μg/kg) of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD) given to pregnant rats at gestational day 15 caused the death or growth retardation of infants. This study suggests that a reduction in infant GH contributes to infant death just after birth, and a reduction in the nursing behaviors of dams due to a reduction in prolactin and other factors contributes to growth delay and sexual immaturity.
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