2011 Fiscal Year Final Research Report
Mechanical stimulation-induced vascular elastogenesis
| Project/Area Number |
22659045
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEDA Satoshi 早稲田大学, 理工学術院, 教授 (30281645)
KATO Takashi 早稲田大学, 教育学術院, 教授 (80350388)
IWASAKI Kiyotaka 早稲田大学, 高等研究所, 准教授 (20339691)
KAGAWA Yuki 早稲田大学, ナノ理工学研究機構, 次席研究員 (90409649)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 組織工学 / 形態形成 / 細胞間相互作用 |
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| Research Abstract |
Vascular elastic fibers play a very important role in maintaining the structure of the arteries. The impairment of elastic fiber formation is closely related with aging and vascular diseases. We hypothesized that mecanical stresses onto the arteries would affect elastic fiber formation. Therefore, we tried to perform the quantitative analysis of the relation between elastic fiber formation and the types and strength of mechanical stresses. We found that elastic fiber formation was promoted in multi-layers of smooth muscle cells or by cycle stretch.
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[Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice2010
Author(s)
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga AI, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S
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Journal Title
Am J Physiol Renal Physiol
Volume: 299(5)
Pages: F991-F1003
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