Single-neuron analysis of strain recognition memory in mice

2011 Fiscal Year Final Research Report

• Project/Area Number: 22659049
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kochi University
• Principal Investigator: KABA Hideto 高知大学, 教育研究部・医療学系, 教授 (50136371)
• Project Period (FY): 2010 – 2011
• Keywords: フェロモン / 交尾 / 副嗅球 / 僧帽細胞 / 顆粒細胞 / ホールセルクランプ法 / c-fosプロモーター / ドキシサイクリン

Research Abstract

We examined the effects of pharmacological and genetic manipulations of mGluR2, a metabotropic glutamate receptor, on synaptic currents measured from mitral or granule cells in slices of the accessory olfactory bulb(AOB), which is a critical site for mate recognition memory in mice. The results indicate that mGluR2 reduces dendrodendritic inhibition of mitral cells by inhibiting excitatory transmission from mitral cells to granule cells in the AOB. We are currently undertaking an experiment to characterize the properties of mitral and granule cells that store the mate recognition memory.

Research Products

• [Journal Article] Accessory olfactory bulb neurons are required for maintenance but not induction of V2R vomeronasal receptor gene expression in vitro (2011)
  • Author(s): Muramoto, K., Hagino-Yamagishi, K., Tonosaki, K. & Kaba, H.
  • Journal Title: Neuroscience Letters Volume: 500 Pages: 6-9
  • Peer Reviewed
• [Journal Article] 絆はどのように生まれるのか.別冊日経サイエンス181「こころと脳のサイエンス」 (2011)
  • Author(s): 椛秀人
  • Journal Title: 特集「赤ちゃんパワーが"親脳"を育てる」 Volume: 181 Pages: 30
• [Journal Article] ヒトのフェロモンと脳内情報処理の性差 (2011)
  • Author(s): 椛秀人
  • Journal Title: 日本医事新報 Volume: No.4573 Pages: 50-51
• [Journal Article] Common properties between synaptic plasticity in the main olfactory bulb and olfactory learning in young rats (2010)
  • Author(s): Zhang, J.-J., Okutani, F., Huang, G.-Z., Taniguchi, M., Murata, Y. & Kaba, H.
  • Journal Title: Neuroscience Volume: 170 Pages: 259-267
  • Peer Reviewed
• [Journal Article] 嗅覚の生理 (2010)
  • Author(s): 椛秀人
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1251-1255
• [Journal Article] Neurobiology of mammalian olfactory learning that occurs during sensitive periods (2010)
  • Author(s): Kaba, H.
  • Journal Title: Current Zoology Volume: 56 Pages: 819-833
• [Presentation] 副嗅球シナプスの長期増強における遅延相の新規蛋白合成依存 (2012)
  • Author(s): 村田芳博,椛秀人
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本市
  • Year and Date: 20120329-31
• [Presentation] 内因性に放出されるグルタミン酸によって活性化される代謝型グルタミン酸受容体mGluR2を介したマウス副嗅球僧帽細胞.顆粒細胞間相反性シナプス伝達の抑制 (2012)
  • Author(s): 谷口睦男,椛秀人
  • Organizer: 第89回日本生理学会年会
  • Place of Presentation: 松本市
  • Year and Date: 20120329-31
• [Presentation] Long-term potentiation at synapses in the mouse accessory olfactory bulb requires new protein synthesis (2011)
  • Author(s): Murata, Y., Kaba, H.
  • Organizer: The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: 福岡市
  • Year and Date: 20111104-06
• [Presentation] Oxytocin and social recognition in mammals (2011)
  • Author(s): Kaba, H.
  • Organizer: The 3^<rd> Global Sensory Branding Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-11
• [Presentation] Suppression of the recurrent inhibition in the mouse accessory olfactory bulb by the metabotropic glutamate receptor mGluR2 through inhibition of high-voltage-activated Ca currents (2010)
  • Author(s): Taniguchi, M. & Kaba, H.
  • Organizer: The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: 福岡市
  • Year and Date: 20101106-07
• [Book] 解剖生理学〔第2版〕 (2012)
  • Author(s): 椛秀人, 他
  • Total Pages: 263
  • Publisher: 化学同人
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm