2011 Fiscal Year Final Research Report
Signaling mechanisms of a novel-type transmembrane receptor 4F2hc
| Project/Area Number |
22659052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMORI Shushi 大阪大学, 大学院・医学系研究科, 助教 (90467572)
OHGAKI Ryuichi 大阪大学, 大学院・医学系研究科, 助教 (20467525)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 受容体 / シグナル情報伝達系 / 輸送体 / 細胞増殖 / リン酸化 / 細胞膜 |
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| Research Abstract |
To reveal the signaling mechanisms mediated by a single-membrane spanning protein 4F2hc upregulated on cellular activation and in cancer cells, we have analyzed molecular complexes involving 4F2hc, preformed comprehensive signaling-pathway analysis using phosphoproteomics and searched for proteins binding to the intracellular domain of 4F2hc. We have found that 4F2hc together with CD147 forms multimolecular complexes with several transporters, the stimulation of 4F2hc/ LAT1 complex activate mTOR pathway without acting on MAPK pathway and an intracellular domain binding protein mediates 4F2hc signaling.
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Research Products
(38 results)
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[Journal Article] Transport of 3-fluoro-L-α-methyl tyrosine by tumor-pregulated amino acid transporter LAT1 : a cause of the tumor uptake in PET2012
Author(s)
Wiriyasermkul, P. Nagamori S, Tominaga H, Oriuchi N, Kaira K, Nakao H, Kitashoji T, Ohgaki R. Tanaka H, Endou H, Endo K, Sakurai H and Kanai Y
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Journal Title
J Nucl Med
Volume: (in press)
Peer Reviewed
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[Journal Article] L-type amino acid transporter 1(LAT1) expression in malignant pleural mesothelioma2011
Author(s)
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Journal Title
Anticancer Res
Volume: 31(12)
Pages: 4075-4082
Peer Reviewed
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[Journal Article] Pathogenic GLUT9 mutations causing renal hypouricemia type 2(RHUC2)2011
Author(s)
Kawamura Y, Matsuo H, Chiba T, Nagamori S, Nakayama A, Inoue H, Utsumi Y, Oda T, Nishiyama J, Kanai Y, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30(12)
Pages: 1105-1111
Peer Reviewed
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[Journal Article] Identification of ABCG2 dysfunction as a major factor contributing to gout2011
Author(s)
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Takada Y, Okada C, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids.
Volume: 30(12)
Pages: 1105-11
Peer Reviewed
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[Journal Article] ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans2011
Author(s)
Nakayama A, Matsuo H, Takada T, Ichida K, Nakamura T, Ikebuchi Y, Ito K, Hosoya T, Kanai Y, Suzuki H, Shinomiya N
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Journal Title
Nucleosides Nucleotides Nucleic Acids.
Volume: 30(12)
Pages: 1091-7
Peer Reviewed
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[Journal Article] Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence2011
Author(s)
Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Journal Title
Anticancer Res
Volume: 31(11)
Pages: 3775-82
Peer Reviewed
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[Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans2011
Author(s)
Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y
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Journal Title
J Neurosci.
Volume: 31(46)
Pages: 16603-10
Peer Reviewed
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[Journal Article] LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer2011
Author(s)
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Kanai Y, Endo M, Kondo H, Nakajima T, Yamamoto N
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Journal Title
Am J Transl Res.
Volume: 3(5)
Pages: 468-78
Peer Reviewed
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[Journal Article] Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis2011
Author(s)
Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K
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Journal Title
Lab Invest
Volume: 91(7)
Pages: 992-1006
Peer Reviewed
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