2011 Fiscal Year Final Research Report
Bone as an endocrine organ
| Project/Area Number |
22659065
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
HINOI Eiichi 金沢大学, 薬学系, 准教授 (70360865)
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| Co-Investigator(Kenkyū-buntansha) |
TAKARADA Takeshi 金沢大学, 薬学系, 助教 (30377428)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨組織 / 骨芽細胞 / 骨細胞 / growth differentiation factor 15 / ホルモン / 骨代謝 / 破骨細胞 / 骨粗鬆症 |
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| Research Abstract |
We identified GDF15 as an endocrine factor secreted from osteocytes. Recombinant GDF15 significantly promoted osteoclastic differentiation. The anti-GDF15 antibody prevented bone loss through inhibiting osteoclastic activation in tibias from mice with femoral artery ligation in vivo. These findings suggest that GDF15 could play a pivotal role in the pathogenesis of bone loss relevant to hypoxia through promotion of osteoclastogenesis after secretion from adjacent osteocytes during disuse and/or ischemia in bone.
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Research Products
(10 results)
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[Journal Article] Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia2012
Author(s)
Hinoi, E., Ochi, H., Takarada, T., Nakatani, E., Iezaki, T., Nakajima, H., Fujita, H., Takahata, Y., Hidano, S., Kobayashi, T., Takeda, S., Yoneda, Y.
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 938-949
DOI
Peer Reviewed
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[Journal Article] Negative regulation of osteoblastogenesis through downregulation of runt-related transcription factor-2 in osteoblastic MC3T3-E1 cells with stable overexpression of the cystine/glutamate antiporter xCT subunit2011
Author(s)
Uno, K., Takarada, T., Takarada-Iemata, M., Nakamura, Y., Fujita, H., Hinoi, E., Yoneda, Y.
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Journal Title
J Cell Physiol
Volume: 226
Pages: 2953-2964
DOI
Peer Reviewed
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[Journal Article] A negative correlation between expression profiles of runt-related transcription factor-2 and cystine/glutamate antiporter xCT subunit in ovariectomized mouse bone2011
Author(s)
Uno, K., Takarada, T., Nakamura, Y., Fujita, H., Hinoi, E., Yoneda, Y., A
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Journal Title
J Pharmacol Sci
Volume: 115
Pages: 309-319
DOI
Peer Reviewed
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