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2011 Fiscal Year Final Research Report

Establishment of the non-invading inspection system for the geriatric disease detects with Maillard reaction products.

Research Project

  • PDF
Project/Area Number 22659068
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionOsaka University

Principal Investigator

KAWAKAMI Shigeki  大阪大学, 産業科学研究所, 特任准教授 (90432509)

Co-Investigator(Kenkyū-buntansha) NAGAI Ryoji  日本女子大学, 家政学部, 講師 (20315295)
Project Period (FY) 2010 – 2011
Keywords糖尿病 / 動脈硬化 / AGE / シグナル増幅反応 / 非侵襲検査
Research Abstract

The very-small-quantity protein of the 1 molecular level was detected by the" signal repetition amplifying method" to which each makes two crosslinking agents which have a bridge construction relation react by turns. Condition examination for detecting efficiently the Maillard reaction products for geriatric diseases was performed, and shortening of detection time was realized.

  • Research Products

    (13 results)

All 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (5 results)

  • [Journal Article] N-(Carboxymethyl) lysine Modification of Elastin Alters Its Biological Properties : Implications for the Accumulation of Abnormal Elastic Fibers in Actinic Elastosis2012

    • Author(s)
      Yoshinaga E, Kawada A, Ono K, Fujimoto E, Wachi H, Harumiya S, Nagai R, Tajima S
    • Journal Title

      J Invest Dermatol

      Volume: 132(2) Pages: 315-323

    • Peer Reviewed
  • [Journal Article] Natural Compounds Containing a Catechol Group Enhance the Formation of N-(carboxymethyl) lysine of the Maillard Reaction2011

    • Author(s)
      Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Mera K, Sakashita N, Takeya M, Ikeda T, Araki T, Nohara T, Nagai R.
    • Journal Title

      Free Radic. Biol.

      Volume: 50(7) Pages: 883-891

    • Peer Reviewed
  • [Journal Article] An autoantibody Against N-(carboxyethyl) lysine(CEL): Possible Involvement in the Removal of CEL-Modified Proteins by Macrophages. Biochem2011

    • Author(s)
      Mera K, Nagai R, Takeo K, Izumi M, Maruyama T, Otagiri M
    • Journal Title

      Biophys. Res. Commun

      Volume: 407(2) Pages: 420-425

    • Peer Reviewed
  • [Journal Article] Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages2011

    • Author(s)
      Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda T
    • Journal Title

      J. Agric. Food Chem

      Volume: 59(9) Pages: 4544-4552

    • Peer Reviewed
  • [Journal Article] N^ω-(carboxymethyl) arginine Accumulates in Glycated Collagen and Klotho-deficient Mouse Skin2011

    • Author(s)
      Shimasaki S, Kubota M, Yoshitomi M, Takagi K, Suda K, Mera K, Fujiwara Y, Nagai R
    • Journal Title

      Anti-Aging Medicine

      Volume: 8(6) Pages: 82-87

    • Peer Reviewed
  • [Journal Article] Renoprotective antioxidant effect of alagebrium in experimental diabetes

    • Author(s)
      Park J, Kwon MK, Huh JY, Choi WJ, Jeong LS, Nagai R, Kim WY, Kim J, Lee TG, Lee HB, Ha H
    • Journal Title

      Nephrol Dial. Transplant

      Volume: (In press)

    • Peer Reviewed
  • [Journal Article] The pentosidine concentration in human blood specimens is affected by heating

    • Author(s)
      Nakano M, Kubota M, Owada S, Nagai R
    • Journal Title

      Amino Acids

      Volume: (In press)

    • Peer Reviewed
  • [Journal Article] Tomatidine, a tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in apoE-deficient mice by inhibiting ACAT

    • Author(s)
      Fujiwara Y, Kiyota N, Tsurushima K, Yoshitomi M, Horlad H, Ikeda T, Nohara T, Takeya M, Nagai R
    • Journal Title

      J Agric Food Chem

      Volume: (In press)

    • Peer Reviewed
  • [Presentation] 糖化とは何か:食品素材を用いた抗糖化とその応用性2011

    • Author(s)
      永井竜児
    • Organizer
      食品開発展2011TTCセミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-10-05
  • [Presentation] Inhibition of AGE formation by catechin and other flavonoids2011

    • Author(s)
      Nagai R, Shimasaki S, Nagai M, Fujiwara Y
    • Organizer
      First International Congress on Cocoa, Coffee and Tea
    • Place of Presentation
      Italy
    • Year and Date
      2011-09-14
  • [Presentation] 老化危険因子としてのAGEsおよびRAGE2011

    • Author(s)
      永井竜児
    • Organizer
      第11回日本抗加齢医学会総会シンポジウム24
    • Place of Presentation
      京都
    • Year and Date
      2011-05-29
  • [Presentation] 糖代謝および脂質代謝を改善する食品成分の探索2011

    • Author(s)
      永井竜児
    • Organizer
      日本学術振興会レドックス生命科学第170委員会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-11
  • [Presentation] カルボニルによる新たな翻訳後修飾機構の解析と老化関連疾患との関連性について2010

    • Author(s)
      永井竜児
    • Organizer
      徳島大学大学院ヘルスバイオサイエンス研究部セミナー
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-05

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Published: 2013-07-31  

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