Optimization and standardization of cultivation for human mesenchymal stem cells derived from differential tissues

2012 Fiscal Year Final Research Report

• Project/Area Number: 22659076
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: HIDA Naoko 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 研究員 (70360112)
• Co-Investigator(Kenkyū-buntansha): UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長(再生医療センター長) (70213486) ; TOYODA Masashi 地方独立行政法人東京都健康長寿医療センター, 研究所老年病研究チーム・血管医学研究, 研究副部長 (50392486)
• Project Period (FY): 2010 – 2012
• Keywords: ES細胞 / 遺伝子解析 / 再生医療 / 細胞移植

Research Abstract

It has been noted that human mesenchymal stem cells are one of the most suitable cell sources. Mesenchymal stem cells exist in many tissues and differ in their property. In this study, we optimized the cultivation system for clinical purpose. We will improve efficacies of the cell products through information sharing.

Research Products

• [Journal Article] Treatment of human mesenchymal stem cells withangiotensin receptor blocker improved efficiency of cardiomyogenic trans differentiation and improved cardiac function via angiogenesis. (2011)
  • Author(s): Numasawa Y, Kimura T, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H, Segawa K, Ogawa S, Umezawa A
  • Journal Title: Stem Cells Volume: 29(9) Pages: 1405-14
• [Journal Article] Pretreatment of human mesenchymal stemcells with pioglitazone improved efficiency of cardiomyogenictransdifferentiation and cardiac function. (2011)
  • Author(s): Shinmura D, Togashi I, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H,Segawa K, Tsukada Y, Ogawa S, Umezawa A
  • Journal Title: Stem Cells Volume: 29(2) Pages: 357-66