2011 Fiscal Year Final Research Report
Mechanisms of bone metastasis of tumor cells by endothelial-mesenchymal transition of vascular endothelial cells.
| Project/Area Number |
22659078
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TSUDA Masumi 北海道大学, 大学院・医学研究科, 助教 (30431307)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 血管内皮細胞 / 内皮間葉移行 / 腫瘍微小環境 / 骨転移 |
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| Research Abstract |
We clarified that human synovial sarcoma and oral cancer cells induced vascular endothelial cells into the tumors by Src-dependent VEGF production and oral environment specific induction of RANKL, respectively. In addition, using in vitro 3D culture system we have established, synovial sarcoma cells aggressively invaded into the tubes formed by HUVECs, leading to the morphological alterations like endothelialmesenchymal transition in HUVECs, resulted in the aberrant tube formation combined with synovial sarcoma cells.
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Research Products
(9 results)
